I'm running XPE NAS in ESXI. I can't run XPE as the O/S since I have a nvidia graphic card to run in another VM(ubuntu) to transcode for emby in ESXI and Xpenology does not have a driver for that.
I will definitely try to put my ESXI on a USB to boot and disable other sata ports.
As for the data store set up, It doesn't seem to matter. I set up a SHR before with all four 4T drives and the 8T drive, and it crashed. I also set up a basic volume with the 8T drive only, and it crashed just this morning. SATA ports and SATA cables were switched so those should not be a problem. The powersupply is a 500w one, seems to have enough power. Also, if it's the problem of the powersupply, drives should crash randomly, but in my case, it was always the 8T one. Right now I can only suspect that if it is the case that Lsi 2308 has some compatibility issue with HGST drives.