Sure it's a annoying options in the loader and/or bios. For example, my old MSI B460I won't boot correctly and stable over the time when DS920+ model is chosen. Why DS918+ it's way more smooth, but I have to be careful with real S/N, MAC, modules, etc... It's a bit long to isolate what is interfering.
Please details full specs of your hardware, loader version, settings chosen, otherwise it's difficult to guide you.