It is possible, you need to add software repository https://spk7.imnks.com
Find Qemu Guest Agent tool
Install it and don't start at first. Then you need to ssh in your Xpeno and run this command, as described:
sudo sed -i 's/package/root/g' /var/packages/qemu-ga/conf/privilege
After that you need to stop Xpeno VM, turn on Qemu Guest Agent in VM options at Proxmox console:
And start your XPeno VM again with working Qemu Guest Agent integration.