Sorry my post has been written before I saw that you have updated your post.
First a short question: If I'm using virtual disks on datastores and using them in XPenology with BTRFS - is it a good way?
Because I'm using then two filesystems? VMFS and BTRFS?
FreeNAS users told me that ZFS shouldn't be run like that, ZFS has to be on the baremetal disks and no layer should be between data and disk except ZFS. ZFS seems to be really critical because of RAM & disks and the latency of USB.
So virtual disks (VMFS) and BTRFS are usable? There's no problem then using it with RAID? And BTRFs doesn't have a problem with USB disks and RAID?